Now why didn't I think of that?!?! That would be so much faster! And it's so much more scenic.
See some of the other threads here for suggestions on where to live downtown or nearby neighborhoods, and what to look for. Ultimately however, you need to walk through some of the neighborhoods. Driving helps you see a lot fast, but if something catches your eye about a neighborhood, get out and walk. Visit a few restaurants, bars and shops, etc. and talk to the bartender, the patrons, the shopkeepers and others. It's the only way to get to know a neighborhood.
Awesome, this is going to help me out a lot, thanks! I'm currently in pittsburgh so hopefully i'll have several chances to drive out and visit the various neighborhoods in the coming weeks